Abstract
kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma.
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Ramos, A. C., Gaspar, V. P., Kelmer, S. M. G., Sellani, T. A., Batista, A. G. U., De Lima Neto, Q. A., … Fernandez, M. A. (2015). The kin17 protein in murine melanoma cells. International Journal of Molecular Sciences, 16(11), 27912–27920. https://doi.org/10.3390/ijms161126072
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