First total synthesis of (+)-vedelianin, a potent antiproliferative agent

Joseph J. Topczewski; David F. Wiemer

Journal Article

First total synthesis of (+)-vedelianin, a potent antiproliferative agent

Tetrahedron Letters (2011) 52(14) 1628-1630

DOI: 10.1016/j.tetlet.2011.01.137

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Abstract

The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S,3R,4aR,9aR)-isomer. © 2011 Elsevier Ltd. All rights reserved.

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Topczewski, J. J., & Wiemer, D. F. (2011). First total synthesis of (+)-vedelianin, a potent antiproliferative agent. Tetrahedron Letters, 52(14), 1628–1630. https://doi.org/10.1016/j.tetlet.2011.01.137

First total synthesis of (+)-vedelianin, a potent antiproliferative agent

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