Heparin-coated bypass circuits: Effects on inflammatory response in pediatric cardiac operations

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Abstract

Background. This study was designed to investigate whether clinical signs of the inflammatory response in pediatric cardiac patients are reduced by heparin-coated cardiopulmonary bypass circuits and how this could be explained by differences in the pathophysiologic mechanisms involved. Methods. In a randomized, prospective Study 19 patients underwent cardiopulmonary bypass either with Carmeda BioActive Surface bypass circuits (n = 9) or with identical noncoated circuits (control, n = 10). Clinical parameters were recorded during the first 48 hours after the start of operation. Blood samples for determination of terminal complement complex, soluble form of E-selectin, and beta-thromboglobulin were obtained perioperatively up to 24 hours after operation. Results. All clinical and inflammatory mediators showed a tendency in favor of the group with heparin- coated circuits. When analyzed on a point-by-point basis there were significant differences in postoperative central body temperature, soluble E- selectin levels, and beta-thromboglobulin levels (all p < 0.05). Conclusions. These data suggest that the use of heparin-coated cardiopulmonary bypass offers clinical benefit and tends to reduce the release of inflammatory mediators.

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Schreurs, H. H., Wijers, M. J., Gu, Y. J., Van Oeveren, W., Van Domburg, R. T., De Boer, J. H., & Bogers, A. J. J. C. (1998). Heparin-coated bypass circuits: Effects on inflammatory response in pediatric cardiac operations. Annals of Thoracic Surgery, 66(1), 166–171. https://doi.org/10.1016/S0003-4975(98)00348-8

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