Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and sinuses. Since fungi were postulated as a potential cause of CRS in the late 1990s, there has been increasing controversy about the use of both topical and systemic antifungal agents in its management. Although interaction between the immune system and fungus has been demonstrated in CRS, this does not necessarily imply that fungi are the cause of CRS or that antifungals will be effective its management.
Sacks, P.-L., Harvey, R. J., Rimmer, J., Gallagher, R. M., & Sacks, R. (2011). Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd008263.pub2