Chemo- and enantioselective catalytic hydrogenation of α,β-unsaturated ketones and aldehydes as a tool to introduce chiral centers at α− or β−positions of ketones

Abstract

Catalytic enantioselective hydrogenations of acyclic and cyclic α,β-unsaturated ketones and aldehydes are useful protocols for introduction of chiral centers at α- and/or β-positions of ketones especially in process scale reactions, which are reviewed in addition to conjugate and organocatalytic transfer reductions from the literatures since 2000.