Electrospun of poly(vinyl alcohol) nanofiber as carrier of Garcinia mangostana L. pericarp extract

Abstract

The extract of Garcinia mangostana pericarp (GP) contains xanthones that possesses diverse therapeutic effects. Nevertheless, it has poor solubility in water and poor absorption. Incorporation of GP extracts in nano-delivery system is a promising way to increase GP extracts solubility and absorption. The objective of this study is to prepare poly(vinyl alcohol) (PVA) mats GP nanofiber by electrospinning method. The nanofibers that contained GP extracts were synthesized in a mixture of PVA using single nozzle electrospinning method. The electrospinning parameters used have 13 kV potential with the nozzle-collector distance of 13 cm and flow rate 10 μl/minute. Scanning electron microscopic (SEM) was evaluated. From the SEM analysis, the average diameter of the fibers was on the nanoscale size. Hence in this study, the PVA nanofiber and PVA/GP nanofiber mats were successfully prepared using the electrospinning method. In addition, applying high voltage in the electrospinning process did not destroy the chemical structure of GP extracts indicated by retained antibacterial activity in vitro. These GP nanofiber mats may provide the good alternative for drug delivery system.