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Oxidative 1,2-Aryl Migration of Alkyl Aryl Ketones by Using Diacetoxyphenyliodine: Syntheses of Arylacetate, 2-Arylpropanoate, and 2-Arylsuccinate

Chemical and Pharmaceutical Bulletin (1985) 33(3) 1097-1103
DOI: 10.1248/cpb.33.1097
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Abstract

Oxidative 1,2-aryl migration of alkyl aryl ketones (2, 5, and 8) to 2-arylalkanoates (3, 6, and 9) was effected by using diacetoxyphenyliodine (1). The migration was successfully applied to the preparation of the antiinflammatory agents ibuprofen (15) and clidanac (17). © 1985, The Pharmaceutical Society of Japan. All rights reserved.

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Tamura, Y., Yakura, T., Shirouchi, Y., & Haruta, J. I. (1985). Oxidative 1,2-Aryl Migration of Alkyl Aryl Ketones by Using Diacetoxyphenyliodine: Syntheses of Arylacetate, 2-Arylpropanoate, and 2-Arylsuccinate. Chemical and Pharmaceutical Bulletin, 33(3), 1097–1103. https://doi.org/10.1248/cpb.33.1097

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