The development of the Sabin-Pinkerton triad despite prenatal screening for congenital toxoplasmosis

Abstract

The paper presents a case of a boy who developed the symptoms of congenital toxoplasmosis: Hydrocephalus, retinitis, choroiditis and intracranial calcifications (the Sabin-Pinkerton triad). Despite prenatal screening in the first trimester of pregnancy (in accordance with the guidelines of the Ministry of Health), which indicated the diagnosis of asymptomatic primary Toxoplasma gondii infection in the pregnant mother, no antiparasitic therapy was used. The presented serological and imaging findings, as well as specialist consultations confirm the intensified effects of congenital infection in the child. Although the child was put on anti-toxoplasma therapy immediately after birth, he developed severe psychophysical development disorders. The paper discusses recommendations for maternal diagnosis and antiparasitic treatment that could have prevented the full-blown congenital toxoplasmosis in the described patient.