Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial

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Abstract

Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).

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Gandhi, M., Bacchetti, P., Ofokotun, I., Jin, C., Ribaudo, H. J., Haas, D. W., … Currier, J. S. (2019). Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial. In Clinical Infectious Diseases (Vol. 68, pp. 1044–1047). Oxford University Press. https://doi.org/10.1093/cid/ciy764

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