Engraftment of HTLV-I-Transformed Human T-Cell Line into SCID Mice with NK Cell Function

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Abstract

HTLV-I-transformed human T-cell line, MT-2, has been reported to successfully proliferate in only the SCID mice with depletion of NK cell function. However, MT-2 cells could be engrafted into SCID mice possessing normal NK cell function in this study. MT-2 cells (5-7 x 107 cells) were intraperitoneally injected into SCID mice without the deletion of NK cell function. The SCID mice developed tumors in the peritoneal cavities 3 months after the inoculation of MT-2 cells. All tumors reacted to anti-HTLV-I pl9 and anti-HLA-DR monoclonal antibodies by immunofluorescence assay and were also positive for the HTLV-I gene by PCR assay. DNA obtained from main organs in group of mice with or without tumors showed a high incidence of positive signals for HTLV-I gene by PCR assay. © 1994, The Keio Journal of Medicine. All rights reserved.

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Nomura, T., Ishibashi, K., & Shingu, M. (1994). Engraftment of HTLV-I-Transformed Human T-Cell Line into SCID Mice with NK Cell Function. Journal of Veterinary Medical Science, 56(3), 601–603. https://doi.org/10.1292/jvms.56.601

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