Abstract
New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Murphy, A. C., Fukuda, D., Song, Z., Hothersall, J., Cox, R. J., Willis, C. L., … Simpson, T. J. (2011). Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. Angewandte Chemie - International Edition, 50(14), 3271–3274. https://doi.org/10.1002/anie.201007029
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