Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

Abstract

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has beendeveloped. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminaryinvestigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and doublestrandedcircular DNA . © 2011 Gulevich et al; licensee Beilstein-Institut.