Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives

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Abstract

A synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl-1,3-diketone-derived α,β-unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). (Figure presented.).

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Muimhneacháin, E., Pardo, L. M., Bateman, L. M., Rao Khandavilli, U. B., Lawrence, S. E., & McGlacken, G. P. (2017). Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives. Advanced Synthesis and Catalysis, 359(9), 1529–1534. https://doi.org/10.1002/adsc.201700062

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