A synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl-1,3-diketone-derived α,β-unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). (Figure presented.).
Muimhneacháin, E., Pardo, L. M., Bateman, L. M., Rao Khandavilli, U. B., Lawrence, S. E., & McGlacken, G. P. (2017). Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives. Advanced Synthesis and Catalysis, 359(9), 1529–1534. https://doi.org/10.1002/adsc.201700062