HR-LC-MS based metabolic profiling of Fusarium solani a fungal endophyte associated with Avicennia officinalis

Abstract

Endophytic fungi form associations with plants, and often assist plant growth and produce bioactive metabolites, which confer resistance against plant pathogens and other stress factors. Mangrove plants being the flora of marshy and saline areas are highly tolerant to salinity and are rich in secondary metabolites. In this study, we isolated and identified Fusarium solani a fungal endophyte from leaves of mangrove, Avicennia officinalis. This endophyte was studied for metabolic profiling and further identification of bioactive compounds using HR-LC-MS based metabolomics. The fungal extract showed the presence of several anti-cancer compounds like 3-Pyridylacetic acid, Aloe-emodin, Antipyrine, Mitoxantrone, Sulfabenzamide etc. This metabolomic study highlights the potential of mangrove associated endophytic fungi for the production of industrially and medicinally important secondary metabolites.