Electrochemical sensor for rapid and sensitive detection of tryptophan by a cu2o nanoparticles- coated reduced graphene oxide nanocomposite

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Abstract

In this paper, a nanocomposite of cuprous oxide and electrochemically reduced graphene oxide (Cu2O‒ERGO) was prepared by a simple and low-cost method; hereby, a new method for the electrochemical determination of tryptophan (Trp) by this composite modified glassy carbon electrode (GCE) is proposed. The prepared materials and modified electrodes were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and cyclic voltammetry (CV). The results showed that Cu2O‒ERGO/GCE had good electrocatalytic activity for Trp. The effects of supporting electrolyte, scanning rate, accumulation potential, and accumulation time on the determination of Trp were studied. Under the optimum experimental conditions, Trp was quantitatively analyzed by square-wave voltammetry (SWV). The oxidation peak current of Trp had a good linear relationship with its concentration in the range of 0.02‒20 μM, and the detection limit was 0.01 μM (S/N = 3). In addition, the modified electrode has high sensitivity, good repeatability, and long-term stability. Finally, the proposed method has been successfully applied in the determination of Trp concentration in practical samples.

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He, Q., Tian, Y., Wu, Y., Liu, J., Li, G., Deng, P., & Chen, D. (2019). Electrochemical sensor for rapid and sensitive detection of tryptophan by a cu2o nanoparticles- coated reduced graphene oxide nanocomposite. Biomolecules, 9(5). https://doi.org/10.3390/biom9050176

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