Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

Abstract

Background: Lipodystrophic Agpat2-/- mice are severely diabetic and insulin resistant. Results: Livers of Agpat2-/- mice have elevated levels of phosphatidic acids (PAs), which enhance gluconeogenesis. Conclusion: PA enhanced hepatic gluconeogenesis contributes to the hyperglycemia present in Agpat2-/- mice. Significance: PA enhanced hepatic gluconeogenesis might have wider implications in understanding the development of hyperglycemia in type 2 diabetes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.