Comparison of the effect of propofol and isoflurane on hemodynamic parameters and stress response hormones during Laparoscopic Cholecystectomy surgery

0Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background and Aims: General anesthesia induces endocrine, immunologic, and metabolic responses. Anesthetic drugs affect endocrine system by changing the level of stress hormones and hemodynamic of the patient. The purpose of this study was to compare the effects of propofol and isoflurane on hemodynamic parameters and stress-induced hormones in laparoscopic cholecystectomy (LC) surgery. Material and Methods: Seventy patients of elective LC were included in this study. Patients were randomly divided into two equal groups of 35 patients; group P received propofol (70-120 μg/kg/min) and group I received isoflurane (mac: 1.28%) as anesthesia maintenance. The following parameters were monitored, checked, and recorded from preanesthesia period to 10 min after PACU entry according to a planned method: hemodynamic parameters (heart rate and mean atrial pressure), level of blood sugar, and serum epinephrine level. Results: Heart rate and mean atrial pressure changes did not show significant differences between the two groups in all stage (P > 0.05), but isoflurane group tolerated lower fluctuating changes. Blood glucose and serum epinephrine level rise in the isoflurane group were significantly higher than the propofol group (P < 0.05). Conclusion: Maintenance anesthesia by inhalation gas base on isoflurane has not shown a significant difference with total intravenous anesthesia base on propofol on hemodynamic parameter. However, propofol has a consistent effect on decreasing stress hormone and suggested for LC surgery.

References Powered by Scopus

General stress response to conventional and laparoscopic cholecystectomy

211Citations
N/AReaders
Get full text

Regulation of blood pressure by the arterial baroreflex and autonomic nervous system

136Citations
N/AReaders
Get full text

The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions

118Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ghomeishi, A., Mohtadi, A., Behaeen, K., Nesioonpour, S., Golbad, E., & Bakhtiari, N. (2022). Comparison of the effect of propofol and isoflurane on hemodynamic parameters and stress response hormones during Laparoscopic Cholecystectomy surgery. Journal of Anaesthesiology Clinical Pharmacology, 38(1), 137–142. https://doi.org/10.4103/joacp.JOACP_146_19

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

63%

Professor / Associate Prof. 2

25%

Researcher 1

13%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

71%

Nursing and Health Professions 1

14%

Engineering 1

14%

Save time finding and organizing research with Mendeley

Sign up for free