Background: Vitamin D deficiency has recently been implicated as a contributory factor in the development of peripheral arterial disease (PAD). Methods: A review of the published literature on PAD and vitamin D was undertaken using Medline, PubMed, and Embase, and cross-referenced. All relevant published papers on the subject were reviewed. Results: Published studies have shown that there is a significant association between vitamin D and PAD. Populations with lower vitamin D levels are more likely to develop PAD in a graded manner. Higher amputation rates are also observed among patients with PAD and lower vitamin D levels. In addition, vitamin D deficiency is significantly associated with increased risk of cardiovascular adverse events. This was also observed in the mouse model where low vitamin D led to the development of atherosclerosis. Conclusion: This study shows that vitamin D deficiency could be an independent risk factor for the development of PAD and that this risk factor is easily correctable. Further studies should look into the effects of vitamin D supplementation in patients with PAD. © 2011 Chua et al, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Chua, G. T., Chan, Y. C., & Cheng, S. W. (2011). Vitamin D status and peripheral arterial disease: Evidence so far. Vascular Health and Risk Management. DOVE Medical Press Ltd. https://doi.org/10.2147/VHRM.S24876
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