Protein adsorption to hydrocephalus shunt catheters: CSF protein adsorption

Abstract

Objective - To assess the quantity and nature of the proteins that adsorb to hydrocephalus shunt catheters after implantation, and to determine whether sufficient could accumulate to obstruct the catheter. Design - Elution of proteins from 102 explanted shunt catheters, with protein assay and electrophoresis of the eluate, and scanning electron microscopy (SEM) of the catheters. Results - The amount of protein elutable was extremely low, and significant protein, apart from a thin film, was not found on SEM. Qualitative analysis disclosed that most of the adsorbed protein was albumin. Conclusions - Protein deposition on hydrocephalus catheters does not occur in sufficient quantities to cause catheter obstruction.