Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α-keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc=tert-butoxycarbonyl, TMS=trimethylsilyl). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Hayashi, Y., Sakamoto, D., Shomura, H., & Hashizume, D. (2013). Asymmetric mannich reaction of α-keto imines catalyzed by diarylprolinol silyl ether. Chemistry - A European Journal, 19(24), 7678–7681. https://doi.org/10.1002/chem.201300513