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In a recent issue of Molecular Cell, Witcher and Emerson (2009) demonstrate that CTCF loss of function, via defective steps in poly (ADP-ribosyl)ation, may predispose key genes in cancer cells to addition of abnormal promoter DNA methylation and silencing. © 2009 Elsevier Inc. All rights reserved.
Tiwari, V. K., & Baylin, S. B. (2009, May 14). Breaching the Boundaries that Safeguard against Repression. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.05.007