Total and percent free prostate-specific antigen levels among U.S. men, 2001-2002

32Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Background: Because total prostate-specific antigen (PSA) and, more recently, the percent free PSA are used to screen men for prostate cancer, population-based, age- and race-specific distributions are needed of both PSA tests among American men to estimate the effect of lowering the PSA threshold or widespread introduction of the free PSA test as an additional screening test. Methods: We did PSA assays on serum samples from men of ages 40 years and older (n = 1,320) who participated in the 2001-2002 National Health and Nutrition Examination Survey. Results: About 6.1% (95% confidence interval, 4.7-7.7%), corresponding to an estimated 3.4 million (range, 2.7-4.3 million) men nationwide, ages 40 years and older, had a total PSA of >4.0 ng/mL. Among men ages 50 to 69 years old, the age group for which PSA testing is most prevalent, 5.4% or an estimated 900,000 to 2 million men had a total PSA of >4.0 ng/mL. An equal number had a total PSA between 2.5 and 4.0 ng/mL and a percent free PSA of <25%. Approximately 27% of men in this age group, corresponding to a range of 5.7 to 8.1 million men, had a total PSA <2.5 ng/mL and a percent free PSA of <25%. Conclusion: The effect of lowering the total PSA threshold or introducing another screening test is significant. Provision of the number of U.S. men with certain total PSA and percent free PSA values may help guide prostate cancer public health policy and screening practices. Copyright © 2005 American Association for Cancer Research.

Cite

CITATION STYLE

APA

Saraiya, M., Kottiri, B. J., Leadbetter, S., Blackman, D., Thompson, T., McKenna, M. T., & Stallings, F. L. (2005). Total and percent free prostate-specific antigen levels among U.S. men, 2001-2002. Cancer Epidemiology Biomarkers and Prevention, 14(9), 2178–2182. https://doi.org/10.1158/1055-9965.EPI-05-0206

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free