The prophylactic approach of sesamol and 3′,4′-(Methylenedioxy)acetophenone to prevent associated cardiotoxicity of doxorubicin at high dose in prostate cancer rat model

Abstract

The clinical application of Doxorubicin (DOX) is restricted due to the incidence of myelotoxicity and cardiotoxicity. Damages caused by free radicles to cardiac muscle tissues are more and permanent. The potent ROS scavenger, Sesamol (SM) has been proven to be effective in diseases related to oxidative stress. Thus, SM can be a good choice for myocardial protection against oxidative stress. 3′,4′-(Methylenedioxy) acetophenone (3’MA) being derivative of SM have been proven in our lab to be antioxidant. Thus, both SM and 3’MA may be having ROS scavenging potential. In this study, we have examined the efficacy of SM and 3’MA protection against toxic effects of DOX at high dose administration in prostate cancer (PCa) induced rats. Results from the study indicate that doxorubicin (4mg/kg) was potent to shows the anticancer activity in prostate cancer but also induce myocardial damage. The histopathological evaluation, Serum creatine kinase-muscle/brain (CK-MB) estimation, heart weight and tibia length ratio and haematology data suggest that the toxicity induced by DOX was prevented by SM and 3’MA treatment. Hence, the hypothesis proposed for this study and data generated from this study shows that SM and 3’MA can be drugs to augment the toxicity of DOX.