FR220897 and FR220899, novel antifungal lipopeptides from Coleophoma empetri no. 14573

Abstract

Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573. This strain was identified as Coleophoma empetri No. 14573 from morphological and physiological characteristics. FR220897 and FR220899 showed antifungal activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-β-glucan synthesis. Furthermore, FR220897 was effective in a murine model of systemic candidiasis. © Japan Antibiotics Research Association.