Zinc (II) [tetra(4-methylphenyl)] porphyrin: A novel and reusable catalyst for efficient synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation

Abstract

An efficient three-component one-step synthesis of 2,4,5-trisubstituted imidazoles by condensation reaction of 1,2-diketones or a-hydroxyketones with aromatic aldehydes and ammonium acetate using Zinc (II) [tetra (4-methylphenyl)] porphyrin as a novel and reusable catalyst under ultrasound irradiation at ambient temperature is described. In this method, a-hydroxyketones as well as 1,2-diketones were converted to their corresponding 2,4,5-trisubstituted imidazoles in excellent yields. Copyright © 2005 KCSNET.