Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery

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Abstract

Purpose: Near-infrared (NIR) fluorescence imaging can provide the surgeon with real-time visualization of, e.g., tumor margins and lymph nodes. We describe and evaluate the Artemis, a novel, handheld NIR fluorescence camera. Procedures: We evaluated minimal detectable cell numbers (FaDu-luc2, 7D12-IRDye 800CW), preclinical intraoperative detection of sentinel lymph nodes (SLN) using indocyanine green (ICG), and of orthotopic tongue tumors using 7D12-800CW. Results were compared with the Pearl imager. Clinically, three patients with liver metastases were imaged using ICG. Results: Minimum detectable cell counts for Artemis and Pearl were 2 × 105 and 4 × 104 cells, respectively. In vivo, seven SLNs were detected in four mice with both cameras. Orthotopic OSC-19-luc2-cGFP tongue tumors were clearly identifiable, and a minimum FaDu-luc2 tumor size of 1 mm3 could be identified. Six human malignant lesions were identified during three liver surgery procedures. Conclusions: Based on this study, the Artemis system has demonstrated its utility in fluorescence-guided cancer surgery.

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van Driel, P. B. A. A., van de Giessen, M., Boonstra, M. C., Snoeks, T. J. A., Keereweer, S., Oliveira, S., … Dijkstra, J. (2015). Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery. Molecular Imaging and Biology, 17(3), 413–423. https://doi.org/10.1007/s11307-014-0799-z

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