Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women with Breast Cancer: The Lifestyle, Exercise, and Nutrition Early after Diagnosis Study

Abstract

PURPOSESuccessful completion of chemotherapy is critical to improve breast cancer outcomes. Relative dose intensity (RDI), defined as the ratio of chemotherapy delivered to prescribed, is a measure of chemotherapy completion and is associated with cancer mortality. The effect of exercise and eating a healthy diet on RDI is unknown. We conducted a randomized trial of an exercise and nutrition intervention on RDI and pathologic complete response (pCR) in women diagnosed with breast cancer initiating chemotherapy.METHODSOne hundred seventy-three women with stage I-III breast cancer were randomly assigned to usual care (UC; n = 86) or a home-based exercise and nutrition intervention with counseling sessions delivered by oncology-certified registered dietitians (n = 87). Chemotherapy dose adjustments and delays and pCR were abstracted from electronic medical records. T-tests and chi-square tests were used to examine the effect of the intervention versus UC on RDI and pCR.RESULTSParticipants randomly assigned to intervention had greater improvements in exercise and diet quality compared with UC (P