Tetracycline resistance determinants in Mycobacterium and Streptomyces species

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Abstract

Two of seven tetracycline-resistant (Tc(r)) Mycobacterium fortuitum group isolates and six Tc(r) clinical Streptomyces isolates carried gram-positive Tc(r) determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the aquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species.

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Pang, Y., Brown, B. A., Steingrube, V. A., Wallace, R. J., & Roberts, M. C. (1994). Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrobial Agents and Chemotherapy. American Society for Microbiology. https://doi.org/10.1128/AAC.38.6.1408

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