Synchronous brain and intravascular B-cell lymphoma after remission of an adult hemophagocytic syndrome

Abstract

Key Clinical Message Hemophagocytic lymphohistiocytosis (HLH) should be considered in the differential diagnosis of adult patients with white matter disease. Brain involvement can be life-threatening and should prompt aggressive therapy. Even after HLH remission, the possibility of subsequent deterioration due to emergence of an aggressive intravascular lymphoma is highlighted here.