New diphenyl ethers from the insect pathogenic fungus Cordyceps sp. BCC 1861

Abstract

Two novel diphenyl ether glycosides and a new diphenyl ether, cordyol A-C (1-3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 μg/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 μg/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 μg/ml. © 2007 Pharmaceutical Society of Japan.