Glucose 6 phosphate dependent pyruvate kinase in Streptococcus mutans

Abstract

Pyruvate kinase of S. mutans JC 2 had an absolute and specific requirement for glucose 6 phosphate. Inorganic phosphate was a strong inhibitor. The enzyme required K+ or NH4+ and Mg2+ or Mn2+. S. mutans FIL and E 49, Streptococcus bovis ATCC 9809, and Streptococcus salivarius ATCC 13419 had also glucose 6 phosphate dependent pyruvate kinases, whereas Streptococcus sanguis NCTC 10904 had an enzyme activated by fructose 1,6 diphosphate.