FORMULATION AND EVALUATION OF TRANSFERSOMAL CREAM OF ACRIFLAVINE

Abstract

A burn can be major medical problems or life-threatening emergencies admitted to any hospital. Conventional topical burn formulations are required to be applied 3 to 4 times a day and previous application is needed to be removed prior to application of each new dose which is very painful to burn patients. In this research an attempt was made to increase the patient compliance by reducing the dosing frequency through sustained release vesicular drug delivery system like transfersomes. Transfersomes were formulated using by thin film hydration method and evaluated for entrapment efficiency, photomicroscopy, scanning electron microscopy, vesicle size, polydispersity and zeta potential. Optimized Transfersomal batch was incorporated in cream base and evaluated for pH, spreadability, viscosity, drug content and in vitro diffusion. Transfersomes prepared by using 1:3 ratio of sodium cholate with cholesterol and 200 mg drug showed highest entrapment (91.65%) and sustained release (65.18% in was 24 hrs) was obtained with transfersomal cream in comparison with conventional formulation (97.54% in 8 hrs).