Morphofunctional changes in the organs of excretion and detoxification with pesticides prolonged low-dose exposure

Abstract

Many toxic substances in low doses daily enter the body of animals and humans with food. In this case, the main burden of the transformation and excretion from the body have the organs of excretion and detoxification. This review summarizes the results obtained on different experimental models and reflecting the impact of pesticides on the gastrointestinal tract, liver and kidneys at low doses chronic intoxication. It is established that, entering the body in low doses, pesticides cause a change in the morphological structure of the intestine and the enzymatic activity of the enterocytes, as well as help reduce the barrier function of the gastrointestinal tract and the development of dysbiosis. When exposed to pesticides there are also changes of biochemical processes in the liver and decrease its functional activity, impaired kidney structure. The original state of health and genetic features of stress-limiting systems determine the severity of the changes and level of post-toxic complications risk.