Improved procedure for the oxidative cleavage of olefins by OsO 4-NaIO4

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Abstract

(Chemical Equation Presented) Oxidative cleavage of olefins by OsO 4-NaIO4 sometimes suffers from low yields due to the formation of side products. It is found that the addition of 2,6-lutidine can suppress the side reactions and dramatically improve the yield of this classic reaction.

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Yu, W., Mei, Y., Kang, Y., Hua, Z., & Jin, Z. (2004). Improved procedure for the oxidative cleavage of olefins by OsO 4-NaIO4. Organic Letters, 6(19), 3217–3219. https://doi.org/10.1021/ol0400342

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