Elimination pathways of fusion protein and peptide drugs

Abstract

Fusion proteins have been known as an interesting subject for scientific researches in improving properties or making a new function by synergistically incorporating two protein domains into one complex. Fusion proteins are created by ligation of two or more protein domains in a single polypeptide with functional properties. Improvement of therapeutic function is one of the main goals for developing these products. Elimination from the body is one of the most important points that should be considered in the design and production of fusion proteins. This review describes some of the most important excretion/elimination pathways of fusion peptide and protein drugs as well as serious elimination challenges in the development and manufacturing of fusion proteins.