The value of splenic preservation with distal pancreatectomy

Abstract

Hypothesis: Splenic-preserving distal pancreatectomy for benign or low-grade malignant disease is associated with decreased perioperative morbidity compared with conventional distal pancreatectomy with splenectomy. Design: A retrospective review of a prospective database of patients. Setting: Memorial Sloan-Kettering Cancer Center, New York, NY. Patients: All patients (N=211) undergoing distal pancreatectomy. Main Outcome Measures: Perioperative complications, length of postoperative stay, and overall survival times were analyzed. Results: After excluding patients with adenocarcinoma and those who had other major organ resection, 125 patients underwent distal pancreatectomy for benign or low-grade malignant disease with splenectomy (n=79) or splenic preservation (n=46). Perioperative complications occurred in 39 (49%) of the 79 patients following splenectomy and 18 (39%) of the 46 patients following splenic preservation (P=.21). Perioperative infectious complications and severe complications were significantly higher in the splenectomy group (28% and 11%) compared with the splenic preservation group (9% and 2%) (P=.01 and .05), respectively. Length of hospital stay was 9 days (range, 5-41 days) following splenectomy and 7 days (range, 5-26 days) following splenic preservation (P