Aspergillus osteomyelitis after liver transplantation

Abstract

A 57-year-old woman underwent liver transplantation and developed osteomyelitis in the femur attributable to Aspergillus fumigatus. The patient was treated successfully with amphotericin B and 5-fluorocytosine for 30 days, and then switched to itraconazole for 12 months. Plasma (1->3)-beta-D-glucan levels decreased significantly after the chemotherapy. Early diagnosis by (1->3)-beta-D-glucan measurement and extended treatment with itraconazole can improve the prognosis of invasive Aspergillus infection.