Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states

3Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

This artice is free to access.

Abstract

Aneurysms of the thoracic aorta are a “silent killer” with no evident clinical signs until the fatal outcome. Molecular and genetic bases of thoracic aortic aneurysms mainly include transforming growth factor beta signaling, smooth muscle contractile units and metabolism genes, and extracellular matrix genes. In recent studies, a role of Notch signaling, among other pathways, has emerged in disease pathogenesis. Notch is a highly conserved signaling pathway that regulates the development and differentiation of many types of tissues and influences major cellular processes such as cell proliferation, differentiation and apoptosis. Mutations in several Notch signaling components have been associated with a number of heart defects, demonstrating an essential role of Notch signaling both in cardiovascular system development and its maintenance during postnatal life. This review discusses the role of Notch signaling in the pathogenesis of thoracic aortic aneurysms considering development and maintenance of the aortic root and how developmental regulations by Notch signaling may influence thoracic aortic aneurysms.

Cite

CITATION STYLE

APA

Malashicheva, A., Kostina, A., Kostareva, A., Irtyuga, O., Gordeev, M., & Uspensky, V. (2020, March 1). Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states. Biochimica et Biophysica Acta - Molecular Basis of Disease. Elsevier B.V. https://doi.org/10.1016/j.bbadis.2019.165631

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free