Abstract
The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold. © 2007 Elsevier Ltd. All rights reserved.
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Simpkins, L. M., Bolton, S., Pi, Z., Sutton, J. C., Kwon, C., Zhao, G., … Hamann, L. G. (2007). Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors. Bioorganic and Medicinal Chemistry Letters, 17(23), 6476–6480. https://doi.org/10.1016/j.bmcl.2007.09.090
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