Antioxidant potency of various mangosteen (Garcinia mangostana,L) pericarp extract fractions on HbA1c and fasting blood glucose level in diabetic mice

Abstract

This study is purposed to explore the antioxidant potency of various mangosteen (Garcinia mangostana L) pericarp extract fractions on HbA1c and fasting blood glucose level in diabetic mice. Study conducted using 3-4 months old male mice as models. Animal models split into 2 main groups; non-STZ normal control group and STZ-treated diabetic mice. STZ induced via multiple low dose method of 30 mg/kg BW administered for 5 days (given daily). Diabetic mice group then divided into 3 subgroups, which were diabetic control group, Metformin-HCl diabetic group, and treatment group given with various mangosteen pericarp extract fractions. Treatment group separated into 3 groups based on various fraction administered; 18 mg/kg BW non-polar (NP) fraction, 80 mg/kg BW semi-polar (SP) fraction, and 50 mg/kg BW polar (P) fraction. All fraction dose equals to 2.5 gram/kg BW of powdered mangosteen pericarp extract dry weight. Control group and various extract fractions treated for 14 days. Body weight, HbA1c, and fasting blood glucose level (after mice fasted for 5-6 hours) measured on 15th day. Result shows significant differences on HbA1c and fasting blood glucose level of treatment group compared to control group, specifically non-polar and polar fraction treatment significantly reduce HbA1c and fasting blood glucose level of diabetic mice.