Abstract
A stress-resistant rat model was introduced. SPORTS (Spontaneously-Running- Tokushima-Shikoku) rats showed significantly shorter time of immobility in the forced swim test compared to control Wister rats. Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats. This model rats are considered to be useful for studying the mechanism of psychological stress.
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Nakaya, Y., Morishima-Yamato, M., Ishida, K., Harada, N., & Nakano, M. (2005). Approach to novel functional foods for stress control 3. Establishment of stress-resistant rat model and its mechanism. In Journal of Medical Investigation (Vol. 52, p. 244). https://doi.org/10.2152/jmi.52.244
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