0772 Early Factors Associated With Preterm Infant Sleep Patterns At Age 1 Year In The EPIPAGE-2 National Birth-Cohort

Abstract

Introduction: Preterm birth is associated with increased risks for several pathologies including neurodevelopmental ones. Studies on sleep patterns among preterm versus non-preterm children provide discordant results. We aimed at describing sleep patterns (i.e. sleep onset difficulties (SOD), night-waking (NW), insomnia symptoms (IS)) and identifying early associated factors at age 1 year among infants born preterm ( <1/night and >=1/night and IS as presence of SOD and NW >=1/night. Early factors studied were education, incomes, family structure, maternal age, parity, tobacco consumption and maternal depression during pregnancy, twin pregnancy, breastfeeding, infant's term, sex, small for gestational age (SGA), comorbidities and perinatal care (skin-to-skin, light protection, specific developmental program). Associations were analyzed by logistic regressions additionally adjusted for infant's neurodevelopment and chronic respiratory treatment, sleep habits and daytime childcare at 1 year old. Result(s): Overall 12%, 62% and 26% of the infants were born at 22-26 WG, 27-31WG and 32-34 WG, respectively. At age 1, SOD, NW (>=1/night) and IS were declared for 56%, 30% and 23% of the infants. In multivariable analyses, infants born at 22-26 WG presented less SOD, NW and IS than those born at 32-34 WG. Being born SGA in a sibship and having a young mother (<25 yo) were also associated with reduced risks for SOD, NW and IS while maternal depression during pregnancy and breastfeeding were associated with slight increased risks. No association was observed between perinatal care and sleep patterns at age 1. Conclusion(s): Parents of infants born extremely preterm or small for gestational age reported less SOD, NW and IS than parents of infant born moderately preterm or normal for gestational age at age 1. Other early factors associated with 1-year-old sleep patterns are similar to those reported in term children.