Abstract
Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.
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Ohsaki, A., Ozawa, M., Komiyama, K., Kishida, A., & Isobe, T. (2012). The cytotoxic activity of diterpenoids from Isodon species. Natural Product Communications, 7(8), 977–978. https://doi.org/10.1177/1934578x1200700803
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