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Expression of hepatitis A virus cDNA in Escherichia coli: antigenic VP1 recombinant protein

  • Ostermayr R
  • von der Helm K
  • Gauss-Müller V
  • et al.
Journal of Virology (1987) 61(11) 3645-3647
DOI: 10.1128/jvi.61.11.3645-3647.1987
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Abstract

The genome of hepatitis A virus (HAV) was reverse transcribed into cDNA and molecularly cloned. cDNA clones coding for the capsid protein VP1 that carries the major HAV antigen were cloned into the expression vector pUR290 and expressed in Escherichia coli. The recombinant fusion protein reacted in an immunoblot with rabbit anti-HAV serum, suggesting that it possesses HAV antigenicity.

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APA

Ostermayr, R., von der Helm, K., Gauss-Müller, V., Winnacker, E. L., & Deinhardt, F. (1987). Expression of hepatitis A virus cDNA in Escherichia coli: antigenic VP1 recombinant protein. Journal of Virology, 61(11), 3645–3647. https://doi.org/10.1128/jvi.61.11.3645-3647.1987

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