Abstract
A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O- 21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23). © 2010 by the authors.
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Zhang, H., Sun, G. Z., Li, X., Pan, H. Y., & Zhang, Y. S. (2010). A new geldanamycin analogue from Streptomyces hygroscopicus. Molecules, 15(3), 1161–1167. https://doi.org/10.3390/molecules15031161
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