Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia

Abstract

(Figure presented.) Appropriate glycemic management in diabetes protects the female germline from hyperglycemia-induced molecular alterations. It is not sufficient though to protect the uterine environment and affects fetal development, suggesting that the uterine environment might be a potential therapeutic target. Improved treatment for patients with type 1 diabetes (T1D) has led to appropriate glycemic management for patients but effects on offspring development persist. Glycemic levels reflecting appropriate glycemic management safeguard the molecular signatures of oocytes from both T1D model mice and human donors. Glycemic levels reflecting appropriate glycemic management fail to protect fetal development from an adverse uterine environment and placental hypoxia.