Skip to main content
ArticleOPEN ACCESS

New psoriasis susceptibility genes: Momentum for skin-barrier disruption

Journal of Investigative Dermatology
DOI: 10.1038/jid.2011.14
18Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C-LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis. © 2011 The Society for Investigative Dermatology.

Cite

CITATION STYLE

APA

Coto, E., Santos-Juanes, J., Coto-Segura, P., & Alvarez, V. (2011). New psoriasis susceptibility genes: Momentum for skin-barrier disruption. Journal of Investigative Dermatology. Nature Publishing Group. https://doi.org/10.1038/jid.2011.14

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free