Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds

Abstract

Three new multiflorane-type triterpenes; 7α-methoxymultiflor-8-ene- 3α,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3α,29- diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3α,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)- diene-3α-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells. © 1996-2013 MDPI AG (Basel, Switzerland).