2,3′-Bisindole Synthesis from o-(2.2-Dibromovinyl)aniline and o-Ethynylaniline

Abstract

A Pd-catalyzed coupling reaction from o-alkynylanilines and o-(2,2-dibromovinyl)anilines for the synthesis of 2,3′-bisindoles is developed. In which, o-ethynylaniline was used as 3-functionalized indole precursor and o-(2,2-dibromovinyl)aniline was used as 2-functionalized indole precursor. This protocol exhibits high efficiency, good functional group tolerance and scalability from easily accessible starting materials.