Influence of Selenium Nanoparticles on The Effects of Poisoning with Aflatoxins

Abstract

The present study was undertaken for the induction of hepatotoxicity by aflatoxicosis and ameliorating their toxic effects in rats by selenium nanoparticles (Se-NPs). Biochemical parameters of all treated rats detected that aflatoxin B1(AFB1) caused a significant decrease in total protein values and electrophoretic patterns, increase in levels of AST and ALT enzymes and decrease in urea. Aflatoxin B1 induced a marked elevation of TNF-α and IL-6 activities and decreased levels of iron, TIBC, UIBC and transferrin. The inflammation caused by AFB1 lead to elevation of hepcidin and, decrease in erythropoietin (EPO) hormones. These changes were improved by administration of Se-NPs to aflatoxicated rats and associated with successful degradation of aflatoxins residues in liver tissues. While, the administration of high dose of Se-NPs (0.5 mg/kg) to aflatoxicated rats resulted in a significant elimination of AFB1 from liver tissues than the low dose (0.3 mg/kg). Hence, it was concluded that Se-NPs can be administrated to the animal for improving the health status from adverse effects of the aflatoxicosis.